- Began writing screenplays at age 10; starred in a production of Grease in elementary school.
- Formed a rap group, Wolfpack, in 1991; has directed videos for rappers Heather B. and Special Ed.
- With his childhood friends Marlon and Shawn Wayans, wrote the theme song for the 1995-99 WB series The Wayans Bros.
- Nominated for an NAACP Image Award, a Black Reel Award, an MTV Movie Award and a Teen Choice Award for his role in the 2000 movie Love & Basketball.
- His mother, a retired New York City public-school administrator, is a minister in Brooklyn.
- Won the NAACP Award for Outstanding Actor in a Drama Series for his portrayal of Dr. Eric Foreman on House two years in a row, in 2007 and 2008.
- Formed his own production company, Brooklyn Works Films.
- Said that playing a doctor on TV makes him ask a lot more questions at his own doctors' appointments.
- His hobbies include boxing and shooting at the gun range.
- Barbecue potato chips are his guilty-pleasure food.
- Said that his writing helps his acting: "I understand characters and it gives me different depth as an actor."
- 2008, Screen Actors Guild Awards — Outstanding Performance by an Ensemble in a Drama Series: Nominee
- Yusra Salama — Ex-significant Other
- Keisha Spivey — Wife
- Aisha Epps — Sister
- Aiyanna Yasmine Epps — Daughter
- Bonnie Epps — Mother
- Amir Epps — Son
- Sanaa Lathan — Ex-significant Other
- K'mari Mae Epps — Daughter
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